A multicenter double‐blind placebo‐controlled trial of pergolide as an adjunct to sinemet® in Parkinson's disease
Identifieur interne : 005C31 ( Main/Exploration ); précédent : 005C30; suivant : 005C32A multicenter double‐blind placebo‐controlled trial of pergolide as an adjunct to sinemet® in Parkinson's disease
Auteurs : Olanow [États-Unis] ; S. Fahn [États-Unis] ; M. Muenter [États-Unis] ; H. Klawans [États-Unis] ; H. Hurtig [États-Unis] ; M. Stern [États-Unis] ; I. Shoulson [États-Unis] ; R. Kurlan [États-Unis] ; J. D. Grimes [Canada] ; Joseph Jankovic [États-Unis] ; M. Hoehn [États-Unis] ; C. H. Markham [États-Unis] ; R. Duvisin [États-Unis] ; O. Reinmuth [États-Unis] ; H. A. Leonard [États-Unis] ; E. Ahlskog [États-Unis] ; R. Feldman [États-Unis] ; L. Hershey [États-Unis] ; M. D. Yahr [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Activities of Daily Living (classification), Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Carbidopa (administration & dosage), Carbidopa (adverse effects), Double-Blind Method, Drug Combinations, Drug Therapy, Combination, Electrocardiography (drug effects), Female, Humans, Levodopa, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Motor Activity (drug effects), Motor Skills (drug effects), Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Parkinson's disease, Pergolide, Pergolide (administration & dosage), Pergolide (adverse effects).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Levodopa, Pergolide.
- chemical , adverse effects : Antiparkinson Agents, Carbidopa, Levodopa, Pergolide.
- classification : Activities of Daily Living.
- drug effects : Electrocardiography, Motor Activity, Motor Skills, Neurologic Examination.
- drug therapy : Parkinson Disease.
- Adult, Aged, Double-Blind Method, Drug Combinations, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.
Abstract
Three hundred and seventy‐six subjects with advanced Parkinson's disease participated in a prospective, double‐blind placebo‐controlled study of the dopamine agonist pergolide mesylate as an adjunct to Sinemet®. At 6 months, patients randomized to pergolide had a statistically singnificant improvement in total Parkinson's score, scores of activities of daily living, motor function, number of “off” hours, Hoehn and Yahr stage, and numerous parameters of parkinsonian function including bradykinesia, rigidity, gait, and dexterity. This benefit was obtained with the addition of a mean dose of 2.94 mg of pergolide, which permitted a 24.7% reduction in dose of levodopa. Adverse reactions were, for the most part, mild, reversible, and not of major clinical significance. No significant cardiac or electrocardiographic abnormalities were detected. This study demonstrates that pergolide mesylate, as an adjunct to levodopa, is an effective antiparkinsonian agent that provides clinical improvement while permitting a reduction in levodopa dose.
Url:
DOI: 10.1002/mds.870090107
Affiliations:
- Canada, États-Unis
- Arizona, Californie, Colorado, Floride, Illinois, Massachusetts, Minnesota, New Jersey, Oregon, Pennsylvanie, Texas, État de New York
- Houston
- Baylor College of Medicine
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Fahn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Muenter, M" sort="Muenter, M" uniqKey="Muenter M" first="M." last="Muenter">M. Muenter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic Scottsdale, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Klawans, H" sort="Klawans, H" uniqKey="Klawans H" first="H." last="Klawans">H. Klawans</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, Rush Presbyterian‐St. Luke's Mediacal Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Hurtig, H" sort="Hurtig, H" uniqKey="Hurtig H" first="H." last="Hurtig">H. Hurtig</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Stern, M" sort="Stern, M" uniqKey="Stern M" first="M." last="Stern">M. Stern</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I." last="Shoulson">I. Shoulson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Grimes, J D" sort="Grimes, J D" uniqKey="Grimes J" first="J. D." last="Grimes">J. D. Grimes</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, Ottawa Civic Hospital, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J." last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Hoehn, M" sort="Hoehn, M" uniqKey="Hoehn M" first="M." last="Hoehn">M. Hoehn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Department of Neurology, University of Colorado, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Markham, C H" sort="Markham, C H" uniqKey="Markham C" first="C. H." last="Markham">C. H. Markham</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Neurology, University of California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Duvisin, R" sort="Duvisin, R" uniqKey="Duvisin R" first="R." last="Duvisin">R. Duvisin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Neurology, Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Reinmuth, O" sort="Reinmuth, O" uniqKey="Reinmuth O" first="O." last="Reinmuth">O. Reinmuth</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Leonard, H A" sort="Leonard, H A" uniqKey="Leonard H" first="H. A." last="Leonard">H. A. Leonard</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>The Neurological Clinic, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Ahlskog, E" sort="Ahlskog, E" uniqKey="Ahlskog E" first="E." last="Ahlskog">E. Ahlskog</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of neurology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Feldman, R" sort="Feldman, R" uniqKey="Feldman R" first="R." last="Feldman">R. Feldman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hershey, L" sort="Hershey, L" uniqKey="Hershey L" first="L." last="Hershey">L. Hershey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Buffalo VA Medical Center, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Yahr, M D" sort="Yahr, M D" uniqKey="Yahr M" first="M. D." last="Yahr">M. D. Yahr</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mt. Sinai Medical Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">64D5EE0FDC2B6B390092EB3128575430429F610D</idno><idno type="DOI">10.1002/mds.870090107</idno><idno type="ArticleID">MDS870090107</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (classification)</term><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (adverse effects)</term><term>Double-Blind Method</term><term>Drug Combinations</term><term>Drug Therapy, Combination</term><term>Electrocardiography (drug effects)</term><term>Female</term><term>Humans</term><term>Levodopa</term><term>Levodopa (administration & dosage)</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (drug effects)</term><term>Motor Skills (drug effects)</term><term>Neurologic Examination (drug effects)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson's disease</term><term>Pergolide</term><term>Pergolide (administration & dosage)</term><term>Pergolide (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term><term>Pergolide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term><term>Pergolide</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Activities of Daily Living</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electrocardiography</term><term>Motor Activity</term><term>Motor Skills</term><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Drug Combinations</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Three hundred and seventy‐six subjects with advanced Parkinson's disease participated in a prospective, double‐blind placebo‐controlled study of the dopamine agonist pergolide mesylate as an adjunct to Sinemet®. At 6 months, patients randomized to pergolide had a statistically singnificant improvement in total Parkinson's score, scores of activities of daily living, motor function, number of “off” hours, Hoehn and Yahr stage, and numerous parameters of parkinsonian function including bradykinesia, rigidity, gait, and dexterity. This benefit was obtained with the addition of a mean dose of 2.94 mg of pergolide, which permitted a 24.7% reduction in dose of levodopa. Adverse reactions were, for the most part, mild, reversible, and not of major clinical significance. No significant cardiac or electrocardiographic abnormalities were detected. This study demonstrates that pergolide mesylate, as an adjunct to levodopa, is an effective antiparkinsonian agent that provides clinical improvement while permitting a reduction in levodopa dose.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Arizona</li><li>Californie</li><li>Colorado</li><li>Floride</li><li>Illinois</li><li>Massachusetts</li><li>Minnesota</li><li>New Jersey</li><li>Oregon</li><li>Pennsylvanie</li><li>Texas</li><li>État de New York</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Olanow" sort="Olanow" uniqKey="Olanow" last="Olanow">Olanow</name></region><name sortKey="Ahlskog, E" sort="Ahlskog, E" uniqKey="Ahlskog E" first="E." last="Ahlskog">E. Ahlskog</name><name sortKey="Duvisin, R" sort="Duvisin, R" uniqKey="Duvisin R" first="R." last="Duvisin">R. Duvisin</name><name sortKey="Fahn, S" sort="Fahn, S" uniqKey="Fahn S" first="S." last="Fahn">S. Fahn</name><name sortKey="Feldman, R" sort="Feldman, R" uniqKey="Feldman R" first="R." last="Feldman">R. Feldman</name><name sortKey="Hershey, L" sort="Hershey, L" uniqKey="Hershey L" first="L." last="Hershey">L. Hershey</name><name sortKey="Hoehn, M" sort="Hoehn, M" uniqKey="Hoehn M" first="M." last="Hoehn">M. Hoehn</name><name sortKey="Hurtig, H" sort="Hurtig, H" uniqKey="Hurtig H" first="H." last="Hurtig">H. Hurtig</name><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J." last="Jankovic">Joseph Jankovic</name><name sortKey="Klawans, H" sort="Klawans, H" uniqKey="Klawans H" first="H." last="Klawans">H. Klawans</name><name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name><name sortKey="Leonard, H A" sort="Leonard, H A" uniqKey="Leonard H" first="H. A." last="Leonard">H. A. Leonard</name><name sortKey="Markham, C H" sort="Markham, C H" uniqKey="Markham C" first="C. H." last="Markham">C. H. Markham</name><name sortKey="Muenter, M" sort="Muenter, M" uniqKey="Muenter M" first="M." last="Muenter">M. Muenter</name><name sortKey="Reinmuth, O" sort="Reinmuth, O" uniqKey="Reinmuth O" first="O." last="Reinmuth">O. Reinmuth</name><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I." last="Shoulson">I. Shoulson</name><name sortKey="Stern, M" sort="Stern, M" uniqKey="Stern M" first="M." last="Stern">M. Stern</name><name sortKey="Yahr, M D" sort="Yahr, M D" uniqKey="Yahr M" first="M. D." last="Yahr">M. D. Yahr</name></country><country name="Canada"><noRegion><name sortKey="Grimes, J D" sort="Grimes, J D" uniqKey="Grimes J" first="J. D." last="Grimes">J. D. Grimes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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